Longevity Voices & Resources

A curated set of the people shaping our approach to longevity — split into the published researchers our biological age model is actually built on, and the popularisers and practitioners who've shaped the wider conversation without being the evidentiary basis for what we build.

Inclusion here is a starting point for your own reading, not an endorsement of every claim. See our methodology and evidence-graded guide for how we assess what actually holds up.

Scientific foundation

Published researchers whose peer-reviewed work informs our model.

Powers Eumaia's Core Algorithm

Dr. Morgan Levine

Creator of PhenoAge — The Algorithm Behind Eumaia

Biological age is not destiny. It is a readout of your current state — and current states can be changed.
Longevity Science

Key Contributions

  • +PhenoAge biological clock algorithm (Yale, 2018)
  • +Epigenetic aging clock research
  • +Gompertz mortality modelling from blood biomarkers
  • +Cellular reprogramming at Altos Labs

Eumaia Impact: The Eumaia Simulator is built directly on her PhenoAge formula — every biological age score you see is her algorithm running on your data.

Steve Horvath, PhD

Inventor of the Horvath Epigenetic Clock · UCLA / Altos Labs

The epigenome is not destiny — it's a readout of how you're living. We've seen meaningful clock reversals with intensive lifestyle interventions.
Longevity Science

Key Contributions

  • +Invented the Horvath epigenetic clock — the first validated biological age measurement from DNA methylation (2013, Genome Biology)
  • +Foundational research underlying the development of GrimAge and PhenoAge
  • +Trained the original clock on 8,000+ samples across 51 tissue types
  • +Continues epigenetic reprogramming research at Altos Labs

Eumaia Impact: His epigenetic clock research laid the scientific foundation PhenoAge was built on. Eumaia's biological age score is a blood-based application of that same underlying approach.

Valter Longo

USC Longevity Institute Director

The fasting mimicking diet can reboot your immune system and promote regeneration.
Fasting

Key Contributions

  • +Fasting Mimicking Diet (FMD) research
  • +Longevity diet principles
  • +Autophagy and cellular regeneration
  • +Cancer and aging intersection research

Eumaia Impact: Fasting-based longevity protocols; ProLon FMD cycles integrated into Eumaia monthly planning

Matt Kaeberlein, PhD

Aging Biology & Rapamycin Researcher · University of Washington

Aging is the greatest risk factor for all of the diseases that kill people.
Longevity Science

Key Contributions

  • +Director, Healthy Aging and Longevity Research Institute (HALo), University of Washington
  • +Founder and co-director of the Dog Aging Project
  • +Leading academic researcher on rapamycin as a geroprotector
  • +Director, NIH Nathan Shock Center of Excellence in the Basic Biology of Aging

Eumaia Impact: His rapamycin and mTOR research is the evidence base cited for Eumaia's rapamycin protocol content — presented as physician-supervised, not a DIY recommendation.

Iñigo San Millán, PhD

Zone 2 & VO2 Max Pioneer

Zone 2 training is the single most powerful intervention for metabolic health and longevity.
Fitness

Key Contributions

  • +Zone 2 training science
  • +VO2 max as longevity metric
  • +Lactate threshold optimization
  • +Mitochondrial health protocols

Eumaia Impact: Established Zone 2 cardio as the cornerstone longevity intervention; trains elite athletes and longevity patients

Matthew Walker

Sleep Scientist and Author

Sleep is the single most effective thing we can do to reset our brain and body health each day.
Sleep

Key Contributions

  • +Sleep and longevity research
  • +REM sleep and memory consolidation
  • +Sleep deprivation and disease risk
  • +Circadian biology optimization

Eumaia Impact: Sleep as the cornerstone of biological age; protocols for deep sleep optimization and circadian alignment

Prof. Tim Spector

Gut Microbiome & Personalised Nutrition Pioneer

We are not what we eat — we are what our microbes eat. Feed them well and they will protect you.
Nutrition

Key Contributions

  • +30 plants per week for microbiome diversity
  • +ZOE personalised nutrition study (15,000+ participants)
  • +Personalised glycaemic response research
  • +Fermented foods and inflammation reduction

Eumaia Impact: Overturned calorie-counting paradigm; microbiome diversity as a longevity lever with direct biomarker impact

Rhonda Patrick

Biomedical Scientist

Optimizing micronutrients can improve health and longevity.
Nutrition

Key Contributions

  • +Sauna and heat stress benefits
  • +Vitamin D optimization
  • +Omega-3 fatty acids research
  • +Cold exposure protocols

Eumaia Impact: Micronutrient optimization; evidence-based supplementation protocols

Ben Bikman, PhD

Insulin Resistance & Metabolic Health Researcher · Brigham Young University

Insulin is the body's master hormone — resistance to it sits upstream of a huge swath of chronic disease.
Metabolic Health

Key Contributions

  • +Professor of Cell Biology & Physiology, BYU
  • +Research on insulin resistance as a driver of obesity, type 2 diabetes, and metabolic disease
  • +HOMA-IR and fasting-insulin optimization frameworks
  • +Ketone metabolism and metabolic flexibility research

Eumaia Impact: His HOMA-IR and fasting-insulin thresholds are the targets used throughout Eumaia's Simulator and monthly plan — the app's insulin-resistance guidance is built on his framework.

Robert Lustig, MD

Metabolic Health & Sugar Researcher · UCSF

Sugar is dangerous because it's sugar. When consumed in excess, it's a toxin.
Metabolic Health

Key Contributions

  • +Professor Emeritus of Pediatrics, Division of Endocrinology, UCSF
  • +Research on fructose metabolism and its role in metabolic disease
  • +Founder, UCSF SugarScience initiative
  • +Author, "Fat Chance" and "Metabolical"

Eumaia Impact: His fructose and metabolic-disease research is part of the published evidence base behind Eumaia's fasting-glucose and triglyceride guidance.

Dr. Stacy Sims

Women's Exercise & Nutrition Science Pioneer

Women are not small men. Stop applying male-derived research to female physiology and expecting the same results.
Women's Health

Key Contributions

  • +Cycle-synced training protocols
  • +Anti-fasting framework for women
  • +Perimenopause strength training protocols
  • +Female-specific protein timing research

Eumaia Impact: The definitive science on what works for female physiology — critical for female Eumaia users whose longevity protocols differ fundamentally from the male-default research

Dr. Nathan Bryan

Nitric Oxide Researcher · Texas A&M Institute for Biosciences

By age 40 you produce half the nitric oxide you did at 20. Restoring NO is the most overlooked cardiovascular intervention in medicine.
Cardiovascular

Key Contributions

  • +Nitric oxide decline as primary driver of cardiovascular aging
  • +Dietary nitrate protocols (beetroot, leafy greens) for NO restoration
  • +mouthwash abolishes NO benefits from diet — critical public health finding
  • +Nasal breathing as a NO delivery system
  • +eNOS uncoupling and how to reverse it

Eumaia Impact: His NO optimization protocol is built into the Eumaia Nitric Oxide page. Directly affects blood pressure, CRP, fasting glucose, and exercise performance — all Eumaia-tracked markers.

Mark Mattson

Intermittent Fasting Researcher · Former Chief, NIA Laboratory of Neurosciences

When you exercise, you activate adaptive stress response pathways.
Fasting

Key Contributions

  • +Intermittent fasting and autophagy
  • +Exercise stress response
  • +Brain health through metabolic switching
  • +Circadian rhythm fasting

Eumaia Impact: Evidence for fasting protocols; metabolic switching and cellular cleanup mechanisms

Voices shaping the longevity conversation

Popularisers and practitioners — not the basis of our model.

Andrew Huberman

Stanford Neuroscientist

Sleep is the foundation of everything in terms of health.
Neuroscience

Key Contributions

  • +Sleep optimization protocols
  • +Light exposure and circadian rhythms
  • +Brain plasticity and neurogenesis
  • +Stress management techniques

Eumaia Impact: Neural optimization; sleep, light, and stress management protocols integrated into daily routines

David Sinclair

Harvard Professor of Genetics

Aging is a disease. And it is treatable.
Genetics

Key Contributions

  • +NAD+ boosters and sirtuin activation
  • +Longevity gene research
  • +Epigenetic age reversal
  • +Exercise and caloric restriction benefits

Eumaia Impact: Foundational aging biology research; resveratrol, NMN, and metformin protocols

Gabrielle Lyon, DO

Muscle-Centric Medicine Founder · Author of Forever Strong

Obesity is not a fat problem — it is a muscle problem. The organ of longevity is skeletal muscle.
Muscle Health

Key Contributions

  • +Muscle-centric medicine framework — muscle as the primary longevity organ
  • +Protein-first approach: ~1g/lb ideal bodyweight, 30–50g at breakfast for mTOR priming
  • +Resistance training as a primary metabolic health intervention
  • +Leucine threshold and mTOR activation research in aging adults

Eumaia Impact: Her muscle-centric framework is the basis of the Eumaia Muscle Longevity page — it tracks HbA1c, fasting glucose, albumin, and testosterone, all biomarkers her research links to muscle mass.

Bryan Johnson

Biohacker and Blueprint Protocol Founder

Don't die. Every decision I make is optimized around not dying.
Biohacking

Key Contributions

  • +Blueprint self-experimentation protocol
  • +Comprehensive multi-organ age measurement
  • +Open-source longevity data sharing
  • +AI-driven health optimization systems

Eumaia Impact: Radical transparency in personal longevity data; Blueprint protocol benchmarks for biological age reversal

Dave Asprey

Founder, Bulletproof · Host, Biohacking Conference

You can't manage what you don't measure. The goal of biohacking is to take full control of your own biology.
Biohacking

Key Contributions

  • +Coined the term "biohacking" — built the movement
  • +Bulletproof Diet and Bulletproof Coffee (MCT/C8 oil protocols)
  • +Cold and heat hormesis for mitochondrial health
  • +40 Years of Zen neurofeedback and HRV optimization

Eumaia Impact: His "measure everything" philosophy overlaps with Eumaia's premise of tracking PhenoAge biomarkers over time; several of his protocols (MCT, cold/heat exposure, HRV) appear in the Eumaia biohacking library.

Commercial Interest: Founder of Bulletproof and other supplement and wellness brands he actively promotes on his own platforms — weigh his protocol recommendations with that commercial interest in mind.

Jason Fung, MD

Nephrologist · Fasting & Insulin Expert · Author of The Obesity Code

Obesity, diabetes, and aging are diseases of high insulin. Lower insulin and you address all three.
Fasting

Key Contributions

  • +Therapeutic fasting for type 2 diabetes reversal
  • +Intermittent fasting and extended fasting protocols
  • +Insulin as the master aging hormone
  • +Intensive Dietary Management program
  • +Autophagy activation through fasting

Eumaia Impact: Fasting protocols and insulin optimisation are mapped directly to Eumaia's glucose and HbA1c biomarkers — the simulator's eating-window intervention (16:8-style time-restricted eating) is grounded in this line of research.

Eric Berg, DC

Chiropractor & Health Educator · Keto & Metabolic Health Content

Your body is not broken. It's been given the wrong instructions.
Nutrition

Key Contributions

  • +Ketogenic diet and fat-burning protocols
  • +Insulin resistance and metabolic health education
  • +Intermittent fasting education
  • +Nutrient deficiency and body type content

Eumaia Impact: His keto and intermittent-fasting content overlaps with topics in Eumaia's nutrition guidance, though he is not a source for Eumaia's underlying methodology.

Commercial Interest: He is a chiropractor (DC) and content creator, not a physician or a researcher publishing peer-reviewed work — his "Dr." title refers to a chiropractic degree, not a medical or academic research credential. He also sells supplements through his own company.

Mark Hyman

Functional Medicine Pioneer

Food is not just calories. It is information that talks to your genes.
Functional Medicine

Key Contributions

  • +Functional medicine framework
  • +Food as medicine approach
  • +Mitochondrial health optimization
  • +Gut-brain-immune axis protocols

Eumaia Impact: Functional medicine integration; root-cause approaches to metabolic disease and longevity

Wim Hof

The Iceman · Creator of the Wim Hof Method

Cold is a noble force. It will show you who you are — and then make you stronger.
Breathwork

Key Contributions

  • +Wim Hof breathing technique (controlled hyperventilation + breath retention)
  • +Cold immersion and voluntary immune system control
  • +Radboud University-validated autonomic control research
  • +HRV improvement through daily breathwork
  • +Brown adipose tissue activation via cold exposure

Eumaia Impact: The breathwork and cold protocols directly target CRP (inflammation) and WBC (immune function) — two of Eumaia's 9 PhenoAge biomarkers

Dr. Tyler LeBaron

Founder, Molecular Hydrogen Institute

Molecular hydrogen is the only antioxidant that selectively neutralizes cytotoxic free radicals without affecting the beneficial signaling ROS that cells need.
Biohacking

Key Contributions

  • +Educator and advocate for therapeutic molecular hydrogen research
  • +H₂ inhalation and hydrogen water protocol design
  • +Nrf2 activation, AMPK, and longevity pathway modulation content
  • +Translation of published H₂ studies into consumer protocols

Eumaia Impact: His hydrogen water and inhalation protocols are the basis of the Eumaia Molecular Hydrogen page.

Commercial Interest: Founder of an institute that promotes and advocates for molecular hydrogen therapy — the modality he researches and teaches is also the one he has an advocacy and commercial interest in.

Dr. Mike Belkowski

Founder, BioLight · Red Light Therapy Specialist

Photobiomodulation is the most evidence-based non-invasive intervention we have — thousands of studies across virtually every tissue type.
Biohacking

Key Contributions

  • +Red light therapy protocols for mitochondrial optimization
  • +Testosterone and DHEA-S support through Leydig cell stimulation claims
  • +Full-body photobiomodulation for systemic anti-inflammatory effect
  • +Wavelength specificity content: 660 nm vs 850 nm applications

Eumaia Impact: His protocols are the basis of the Eumaia Red Light Therapy page.

Commercial Interest: Founder of BioLight, which manufactures and sells the red light therapy devices his protocols recommend.

Dr. Jason Sonners

Founder, HBOT USA · Hyperbaric Oxygen Therapy Specialist

HBOT is not alternative medicine — it has FDA clearance and decades of clinical use.
Biohacking

Key Contributions

  • +Clinical HBOT protocols for longevity, TBI, long COVID, and recovery
  • +Translation of published telomere/senescent-cell HBOT research into consumer-facing protocols
  • +Home vs. clinical HBOT guidance for longevity use

Eumaia Impact: His protocols are the basis of the Eumaia HBOT page.

Commercial Interest: Founder of HBOT USA, a hyperbaric oxygen therapy clinic and equipment business — the modality he advocates for is also his business.

Dan Pardi

Sleep Researcher · Founder, Human OS & Loop Lab

Sleep is not a lifestyle choice. It is the biological foundation that determines how every other health behavior performs.
Sleep

Key Contributions

  • +Human OS framework: light, temperature, and schedule as the three sleep levers
  • +Sleep as a performance metric — tracking and optimizing sleep architecture
  • +Circadian biology applied to daily behavioral design
  • +Loop Lab research on wearables and sleep measurement
  • +Diet, exercise, and sleep interaction research

Eumaia Impact: His Human OS sleep framework is the foundation of the Eumaia Sleep Architecture page. Sleep quality directly affects CRP, cortisol, testosterone, and glucose — all tracked Eumaia markers.

Stuart McGill

Spine Biomechanics Expert

Longevity includes the ability to move pain-free throughout life.
Movement

Key Contributions

  • +Spinal health and injury prevention
  • +Movement quality over intensity
  • +Core stability protocols
  • +Longevity-focused exercise design

Eumaia Impact: Movement and exercise safety; injury-free protocols for lifetime fitness

Dr. William Li

Vascular Biologist & Food as Medicine Pioneer

Your body has the ability to fight disease on its own — if you give it the right foods, it can heal itself.
Nutrition

Key Contributions

  • +Angiogenesis and disease prevention research
  • +Five defence systems activated by food
  • +Stem cell nutrition and vascular regeneration
  • +MediterAsian diet for longevity

Eumaia Impact: Food as precise medicine; angiogenesis, microbiome, and DNA protection protocols mapped to biomarker optimization

Dr. Stephanie Venn-Watson

Veterinary Epidemiologist · Discoverer of C15:0

C15:0 is the first essential fatty acid to be identified in over 90 years.
Nutrition

Key Contributions

  • +Identified C15:0 (pentadecanoic acid) as a proposed essential fatty acid
  • +Discovered C15:0 while investigating Navy dolphin longevity
  • +Published a 2023 Nature Scientific Reports essentiality paper
  • +Developed Fatty15 supplement (FA15™ pure C15:0)

Eumaia Impact: Her C15:0 discovery is the basis of the Eumaia C15:0 protocol page.

Commercial Interest: Founder of Fatty15, the commercial C15:0 supplement her own published research is used to justify — evaluate her essentiality claims independently of her product marketing.

Dale Bredesen

Alzheimer's Prevention Researcher

Brain Health

Key Contributions

  • +ReCODE protocol for Alzheimer's prevention
  • +Metabolic and toxin drivers of neurodegeneration
  • +Personalized brain health optimization
  • +ApoE4 risk mitigation strategies

Eumaia Impact: His APOE4 research on Alzheimer's risk overlaps with the topic Eumaia's own APOE genotype analysis covers, though Eumaia's implementation is not built on the ReCODE protocol.

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